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N-Methoxy-N-methylpyridine-4-carboxamide

  • CAS No. 100377-32-0

  • Cat. No. CS-0123032
  • Purity≥98%
  • MDL No.MFCD03837728
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

N-Methoxy-N-methylpyridine-4-carboxamide|CS-0123032

Structure of 100377-32-0

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Description

N-Methoxy-N-methylpyridine-4-carboxamide features a pyridine-4-carboxamide core with orthogonal N-methoxy and N-methyl groups, enabling selective reactivity in amidation and coupling processes. This bench-stable derivative delivers efficient amide bond formation under mild conditions, offering enhanced solubility and reduced side reactions compared to traditional acylating agents.

Application

N-Methoxy-N-methylpyridine-4-carboxamide serves as a versatile acyl transfer reagent in peptide synthesis and small molecule derivatization. Its pyridine-4-carboxamide core enables efficient coupling with carboxylic acids under mild conditions, while the N-methoxy-N-methyl group enhances electrophilicity and facilitates clean reaction progress. The compound exhibits good bench stability, ease of handling, and compatibility with diverse functional groups, making it a reliable choice for iterative synthetic sequences and API intermediate construction.

General Information

  • CAS No. 100377-32-0
  • Cat. No. CS-0123032
  • Purity ≥98%
  • MDL No. MFCD03837728
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀N₂O₂
  • Molecular Weight 166.18
  • Synonym(s) N-Methoxy-N-methylisonicotinamide
  • SMILES O=C(C1=CC=NC=C1)N(OC)C

Computational Chemistry Data

  • TPSA   42.43
  • LogP   0.715
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

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