N-Ethynyl-N,4-dimethylbenzenesulfonamide

Name: N-Ethynyl-N,4-dimethylbenzenesulfonamide
Brand: ChemScene
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CAS No. 1005500-75-3
Cat. No. CS-0131107
Purity≥96%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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N-Ethynyl-N,4-dimethylbenzenesulfonamide|CS-0131107

Structure of 1005500-75-3

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Description

N-Ethynyl-N,4-dimethylbenzenesulfonamide features a terminal alkyne group appended to a sulfonamide scaffold bearing para-methyl substituents. This configuration enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation and click chemistry applications. The electron-rich aryl moiety enhances solubility in organic solvents, while the bench-stable alkyne facilitates handling under standard conditions.

Application

N-Ethynyl-N,4-dimethylbenzenesulfonamide serves as a versatile building block in synthetic organic chemistry, enabling efficient access to functionalized alkynes via coupling reactions. The sulfonamide group enhances stability and solubility, while the terminal alkyne facilitates palladium- and copper-catalyzed transformations such as Sonogashira and click chemistry. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for constructing complex molecular architectures in medicinal chemistry and materials science applications.

General Information

CAS No. 1005500-75-3
Cat. No. CS-0131107
Purity ≥96%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₁NO₂S
Molecular Weight 209.26
Synonym(s) N-Methylynetoluenesulfonamide
SMILES C#CN(C)S(C1=CC=C(C=C1)C)(=O)=O

Computational Chemistry Data

TPSA 37.38
LogP 1.20622
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

General Reagents Condensation Reaction & Active Esterification

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Peptide Coupling Agents

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Peptide Coupling Agents

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N-Ethynyl-N,4-dimethylbenzenesulfonamide

CAS No. 1005500-75-3

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