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CS-W001157 4
Total: USD 88.00

8-Iodoquinoline

  • CAS No. 1006-47-9

  • Cat. No. CS-0041399
  • Molecule weight255.06
  • Purity≥97%
  • MDL No.MFCD08062396

*For research and further manufacturing use only, not for direct human use.

8-Iodoquinoline|CS-0041399

Structure of 1006-47-9

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General Information

  • CAS No. 1006-47-9
  • Cat. No. CS-0041399
  • Purity ≥97%
  • MDL No. MFCD08062396
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆IN
  • Molecular Weight 255.06
  • Synonym(s) Quinoline,8-iodo
  • SMILES IC1=C2N=CC=CC2=CC=C1

Description

8-Iodoquinoline delivers a potent iodine substituent at the quinoline scaffold, enabling direct functionalization in cross-coupling reactions. This electron-deficient heterocycle combines enhanced reactivity with bench-stable handling, making it ideal for constructing complex pharmaceutical intermediates and materials precursors under standard conditions.

Application

8-Iodoquinoline serves as a versatile building block in synthetic organic chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-established reactivity profile. The iodine substituent facilitates efficient C–C and C–heteroatom bond formation under standard conditions, while the quinoline core provides inherent stability and orthogonal functionality for further derivatization. Its bench-stable nature and compatibility with diverse reaction environments make it a practical choice for constructing complex heterocyclic scaffolds in medicinal chemistry and materials science applications.

Synthesis

  • Route1
    • null|null
      91-22-5
    • ~48%
    • In-stock
      2-Iodoquinoline|CS-0037774
      6560-83-4
    • In-stock
      8-Iodoquinoline|CS-0041399
      1006-47-9

    References

    • Organic Letters, , vol. 13, # 15 p. 4024 - 4027

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.8394
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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