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Structure of 101066-57-3
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4-Nitro-3-(trifluoromethyl)benzaldehyde features a para-nitro group and a sterically accessible trifluoromethyl substituent flanking an aldehyde handle. This electron-deficient aromatic scaffold enables direct coupling in transition-metal-catalyzed cross-couplings and facilitates efficient imine formation under mild conditions. The compound exhibits bench-stable handling characteristics and integrates readily into complex molecular architectures requiring polar, electron-poor aryl motifs.
4-Nitro-3-(trifluoromethyl)benzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to substituted heterocycles via condensation and cyclization reactions. Its electron-deficient aromatic core enhances reactivity in nucleophilic additions, while the trifluoromethyl group imparts metabolic stability and modulates lipophilicity. Bench-stable and readily purified by recrystallization, it functions reliably in standard synthetic workflows involving imine formation, Ugi-type coupling, or transition-metal-catalyzed transformations.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: