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Structure of 1018678-39-1
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4-Chloro-2-(trifluoromethyl)nicotinic acid features a trifluoromethyl group at the 2-position and a chlorine substituent at the 4-position of the pyridine ring, imparting strong electron-withdrawing character. This configuration enhances reactivity in coupling processes and improves metabolic stability, making it valuable for synthesizing bioactive heterocycles in medicinal chemistry and agrochemical development.
4-Chloro-2-(trifluoromethyl)nicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its electron-deficient pyridine core facilitates nucleophilic substitution and palladium-catalyzed coupling reactions, while the trifluoromethyl group enhances metabolic stability and lipophilicity. The molecule exhibits excellent bench stability and is compatible with standard purification methods, making it well-suited for scalable synthesis and process development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H320-H335
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Precautionary Statements : P264-P270-P330
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Lot numbers can be found on the outside label of a product: