4-Bromo-2-chloro-5-methoxypyridine

Name: 4-Bromo-2-chloro-5-methoxypyridine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1020253-15-9
Cat. No. CS-W006134
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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4-Bromo-2-chloro-5-methoxypyridine|CS-W006134

Structure of 1020253-15-9

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Description

4-Bromo-2-chloro-5-methoxypyridine is a halogenated pyridine derivative featuring strategically positioned bromo, chloro, and methoxy substituents. This combination enables selective functionalization in cross-coupling reactions, serving as a key intermediate in the synthesis of bioactive heterocycles. The molecule exhibits enhanced stability under standard conditions and facilitates efficient derivatization in medicinal chemistry workflows.

Application

4-Bromo-2-chloro-5-methoxypyridine serves as a versatile building block in medicinal chemistry and heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromo group facilitates efficient Suzuki, Stille, or Negishi coupling, while the chloro and methoxy substituents provide steric and electronic control. This compound exhibits excellent bench stability and is readily purified by flash chromatography, making it ideal for scalable synthesis of complex pyridine-based scaffolds.

General Information

CAS No. 1020253-15-9
Cat. No. CS-W006134
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅BrClNO
Molecular Weight 222.47
Synonym(s) None
SMILES COC1=CN=C(Cl)C=C1Br

Computational Chemistry Data

TPSA 22.12
LogP 2.5061
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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4-Bromo-2-chloro-5-methoxypyridine

CAS No. 1020253-15-9

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