Lot numbers can be found on the outside label of a product:
3-Chloro-2-methylquinoline
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CAS No. 10222-49-8
- Cat. No. CS-0152743
- Purity≥98%
- MDL No.MFCD08705677
*For research and further manufacturing use only, not for direct human use.
Structure of 10222-49-8
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General Information
- CAS No. 10222-49-8
- Cat. No. CS-0152743
- Purity ≥98%
- MDL No. MFCD08705677
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₀H₈ClN
- Molecular Weight 177.63
- Synonym(s) Quinoline,3-chloro-2-methyl
- SMILES CC1=NC2=CC=CC=C2C=C1Cl
Description
3-Chloro-2-methylquinoline is a heterocyclic compound featuring a quinoline core with chlorine at the 3-position and a methyl group at the 2-position. This electron-deficient scaffold integrates readily into transition-metal-catalyzed coupling reactions, serving as a pivotal building block in medicinal chemistry and materials science due to its stability and predictable reactivity.
Application
3-Chloro-2-methylquinoline serves as a versatile heterocyclic building block in medicinal chemistry and materials science. Its electron-deficient quinoline core, combined with orthogonal functional handles—chlorine at C3 and methyl at C2—enables directed metal-catalyzed coupling reactions, including Suzuki-Miyaura and Buchwald-Hartwig transformations. The molecule exhibits good bench stability and facilitates efficient derivatization under standard reaction conditions, making it well-suited for the synthesis of complex pharmaceutical scaffolds and functionalized ligands.
Synthesis
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Route1
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76-40-4 -
142-04-1
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In-stock
10222-49-8
References
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Busch; Koenigs Chemische Berichte, 1891 , vol. 24, p. 3963
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Route2
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67-66-3
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In-stock
609-72-3 - ~4%
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91-22-5
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611-32-5
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In-stock
10222-49-8
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95-53-4
References
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Busby, Reginald E.; Hussain, Syed M.; Mohamed, Murtedza bin; Parrick, John; Shaw, C. J. Granville; et al. Journal of Chemical Research, Miniprint, 1980 , # 12 p. 4935 - 4953
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Route3
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69239-48-1
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74497-02-2
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In-stock
10222-49-8
References
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Eastman Kodak Co. Patent: US2507146 , 1946 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 12.89
- LogP 3.19662
- H_Acceptors 1
- H_Donors 0
- Rotatable_Bonds 0
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Key Words
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