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Structure of 102236-19-1
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5-(tert-Butyl)-2-chloropyridine features a sterically hindered tert-butyl group at the 5-position, enhancing stability and solubility in organic media. The electron-deficient 2-chloro substituent enables efficient coupling reactions, particularly in palladium-catalyzed cross-couplings. This structural combination facilitates the synthesis of complex pyridyl architectures with improved functional group tolerance and reduced side reactivity under standard conditions.
5-(tert-Butyl)-2-chloropyridine serves as a versatile building block in medicinal chemistry, enabling regioselective functionalization at the 3-position via transition-metal-catalyzed cross-coupling. The electron-deficient pyridine ring and sterically shielded tert-butyl group enhance stability and facilitate purification, while the chlorine substituent provides reliable reactivity in Pd-catalyzed reactions. This compound functions effectively in the synthesis of complex heterocyclic scaffolds and API intermediates under standard reaction conditions.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302+H312-H315-H412
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Precautionary Statements : P264-P270-P273-P280-P302+P352-P330-P362+P364-P501
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Lot numbers can be found on the outside label of a product: