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CS-W001157 4
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Methyl-4-bromothiazole-2-carboxylate

  • CAS No. 1025468-06-7

  • Cat. No. CS-0036359
  • Purity≥97%
  • MDL No.MFCD11114545

*For research and further manufacturing use only, not for direct human use.

Methyl-4-bromothiazole-2-carboxylate|CS-0036359

Structure of 1025468-06-7

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General Information

  • CAS No. 1025468-06-7
  • Cat. No. CS-0036359
  • Purity ≥97%
  • MDL No. MFCD11114545
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄BrNO₂S
  • Molecular Weight 222.06
  • Synonym(s) Methyl 4-bromo-2-thiazole-carboxylate
  • SMILES COC(=O)C1=NC(=CS1)Br

Description

Methyl-4-bromothiazole-2-carboxylate is a bench-stable, moisture-tolerant heterocyclic building block featuring a brominated thiazole core. This compound integrates readily into cross-coupling reactions and serves as a key intermediate in the synthesis of bioactive thiazole derivatives.

Application

Methyl-4-bromothiazole-2-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its well-defined bromine handle. The thiazole core provides excellent stability and compatibility with diverse functional groups, facilitating efficient derivatization for pharmaceutical intermediates. Its bench-stable nature and straightforward purification support scalable applications in medicinal chemistry and process development.

Synthesis

  • Route1
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      67-56-1
    • In-stock
      4-Bromo-1,3-thiazole-2-carboxylic acid|CS-W006047
      88982-82-5
    • ~%
    • In-stock
      Methyl-4-bromothiazole-2-carboxylate|CS-0036359
      1025468-06-7

    References

    • MERCK and CO., INC. Patent: WO2008/57336 A2, 2008 ; Location in patent: Page/Page column 36 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   1.6922
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   1

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