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CS-W001157 4
Total: USD 88.00

3-Bromo-5-(trifluoromethyl)phenol

  • CAS No. 1025718-84-6

  • Cat. No. CS-W019235
  • Purity≥97%
  • MDL No.MFCD11041083

*For research and further manufacturing use only, not for direct human use.

3-Bromo-5-(trifluoromethyl)phenol|CS-W019235

Structure of 1025718-84-6

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General Information

  • CAS No. 1025718-84-6
  • Cat. No. CS-W019235
  • Purity ≥97%
  • MDL No. MFCD11041083
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄BrF₃O
  • Molecular Weight 241.01
  • Synonym(s) 3-Bromo-5-trifluoromethylphenol
  • SMILES OC1=CC(C(F)(F)F)=CC(Br)=C1

Description

3-Bromo-5-(trifluoromethyl)phenol features a trifluoromethyl group that imparts enhanced electron-withdrawal and metabolic stability, while the bromo substituent enables facile cross-coupling reactions. This combination facilitates efficient integration into complex molecular architectures under standard conditions.

Application

3-Bromo-5-(trifluoromethyl)phenol serves as a versatile building block for the synthesis of functionalized aromatic scaffolds, enabling efficient palladium-catalyzed cross-coupling reactions. The bromo group facilitates Suzuki, Stille, and Negishi couplings, while the phenolic hydroxyl offers direct derivatization potential. Its stability under standard reaction conditions and compatibility with diverse functional groups make it ideal for constructing complex heterocycles and bioactive molecules in medicinal chemistry workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   3.1735
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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