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H-Dab(Boc)-OH

  • CAS No. 10270-94-7

  • Cat. No. CS-0099795
  • Molecule weight218.25
  • Purity≥97%
  • MDL No.MFCD00236842

*For research and further manufacturing use only, not for direct human use.

H-Dab(Boc)-OH|CS-0099795

Structure of 10270-94-7

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General Information

  • CAS No. 10270-94-7
  • Cat. No. CS-0099795
  • Purity ≥97%
  • MDL No. MFCD00236842
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₈N₂O₄
  • Molecular Weight 218.25
  • Synonym(s) None
  • SMILES O=C([C@H](CCNC(OC(C)(C)C)=O)N)O

Description

H-Dab(Boc)-OH is a bench-stable, moisture-tolerant amino acid derivative featuring a protected diamino butane backbone. This Boc-protected lysine surrogate integrates readily into peptide chains, enabling efficient access to polybasic sequences in synthetic biology and medicinal chemistry workflows.

Application

H-Dab(Boc)-OH serves as a protected diamino acid building block, enabling efficient incorporation of 1,4-diaminobutane units into peptide and peptidomimetic architectures. The Boc group provides robust protection under standard synthetic conditions, facilitating orthogonal deprotection workflows. Its stability, compatibility with common coupling reagents, and utility in solid-phase synthesis make it a practical choice for constructing bioactive scaffolds and macrocyclic compounds.

Synthesis

  • Route1

    References

    • Huang, Hui; Martasek, Pavel; Roman, Linda J.; Masters, Bettie Sue Siler; Silverman, Richard B. Journal of Medicinal Chemistry, 1999 , vol. 42, # 16 p. 3147 - 3153
  • Route2
    • null|null
      13558-07-1
    • ~%
    • In-stock
      H-Dab(Boc)-OH|CS-0099795
      10270-94-7

    References

    • Poduska,K. Collection of Czechoslovak Chemical Communications, 1966 , vol. 31, p. 2955 - 2972
  • Route3
    • null|null
      1070-19-5
    • ~%
    • In-stock
      H-Dab(Boc)-OH|CS-0099795
      10270-94-7

    References

    • Poduska,K. Collection of Czechoslovak Chemical Communications, 1966 , vol. 31, p. 2955 - 2972

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   101.65
  • LogP   0.3131
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   4

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