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Structure of 102771-66-4
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5-(Trifluoromethoxy)picolinic acid features a trifluoromethoxy group at the pyridine ring's 5-position, delivering enhanced electron-withdrawing character and metabolic stability. This configuration improves solubility in polar solvents and facilitates direct coupling in peptide synthesis and medicinal chemistry applications.
5-(Trifluoromethoxy)picolinic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its trifluoromethoxy group imparts enhanced metabolic stability and lipophilicity, while the pyridine carboxylic acid core enables facile derivatization via amide formation, esterification, or metal-catalyzed coupling reactions. The compound exhibits excellent bench stability and is compatible with standard purification methods, facilitating integration into diverse synthetic workflows.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H317
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Precautionary Statements : P264-P270-P330-P405-P501
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Lot numbers can be found on the outside label of a product: