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CS-W001157 4
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Sodium ((2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl phosphate

  • CAS No. 103226-10-4

  • Cat. No. CS-W013887
  • Purity≥98%
  • MDL No.MFCD22374067

*For research and further manufacturing use only, not for direct human use.

Sodium ((2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl phosphate|CS-W013887

Structure of 103226-10-4

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General Information

  • CAS No. 103226-10-4
  • Cat. No. CS-W013887
  • Purity ≥98%
  • MDL No. MFCD22374067
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀FN₂Na₂O₈P
  • Molecular Weight 370.14
  • Synonym(s) 5-Fluoro-2'-deoxyuridine 5'-monophosphate sodium salt
  • SMILES O[C@H]1C[C@H](N2C(NC(C(F)=C2)=O)=O)O[C@@H]1COP([O-])([O-])=O.[Na+].[Na+]

Description

FdUMP (CAS 103226-10-4) irreversibly inhibits thymidylate synthase, disrupting de novo thymidine triphosphate synthesis and inducing DNA replication stress in rapidly dividing cells.

Application

5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt (CAS 103226-10-4) inhibits thymidylate synthase activity by mimicking deoxyuridine monophosphate, disrupting DNA synthesis in rapidly dividing cells. This makes it a potent anti-mitotic agent. Researchers use it to culture mouse primary cortical neurons and study enzyme function in nucleotide metabolism.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS08
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302+H312+H332-H351
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P405-P501

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Computational Chemistry Data

  • TPSA   156.74
  • LogP   -8.8226
  • H_Acceptors   9
  • H_Donors   2
  • Rotatable_Bonds   4

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