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Structure of 103438-85-3
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4-Fluoro-3-hydroxybenzaldehyde features a strategically positioned aldehyde group flanked by electron-withdrawing fluorine and hydrogen-bonding hydroxyl functionalities. This combination enhances reactivity in nucleophilic addition reactions while maintaining stability under standard bench conditions. The ortho-hydroxyl enables chelation with metal catalysts, facilitating efficient transition-metal-coupled transformations. A valuable scaffold for synthesizing bioactive heterocycles and functionalized aromatic intermediates.
4-Fluoro-3-hydroxybenzaldehyde serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the phenolic hydroxyl and aldehyde groups. Its ortho-hydroxyfluoro substitution pattern facilitates intramolecular cyclizations and enhances metabolic stability in target scaffolds. The compound exhibits good bench stability and compatibility with common protecting group strategies, allowing for efficient diversification in multi-step syntheses.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: