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Structure of 10419-77-9
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Diethyl (iodomethyl)phosphonate features a reactive iodomethyl group enabling direct C–H functionalization. This phosphonate reagent integrates readily into synthetic sequences requiring selective alkylation, offering high stability and compatibility with diverse reaction conditions.
Diethyl (iodomethyl)phosphonate serves as a versatile synthon for the introduction of both phosphonyl and iodomethyl groups in synthetic organic chemistry. It functions as a key reagent in the synthesis of phosphonate-containing building blocks, enabling efficient C–P bond formation via nucleophilic substitution. Its iodomethyl moiety facilitates subsequent cross-coupling reactions, including Stille and Suzuki-Miyaura processes, while the diethyl phosphonate group exhibits good bench stability and compatibility with common protecting groups. The compound is particularly useful in constructing functionalized heterocycles and peptide-linked phosphonates.
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Lot numbers can be found on the outside label of a product: