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CS-W001157 4
Total: USD 88.00

Fmoc-Lys-OH

  • CAS No. 105047-45-8

  • Cat. No. CS-W008176
  • Molecule weight368.43
  • Purity≥95%
  • MDL No.MFCD00038539

*For research and further manufacturing use only, not for direct human use.

Fmoc-Lys-OH|CS-W008176

Structure of 105047-45-8

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General Information

  • CAS No. 105047-45-8
  • Cat. No. CS-W008176
  • Purity ≥95%
  • MDL No. MFCD00038539
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₁H₂₄N₂O₄
  • Molecular Weight 368.43
  • Synonym(s) (((9H-Fluoren-9-yl)methoxy)carbonyl)-L-lysine
  • SMILES NCCCC[C@@H](C(O)=O)NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O

Description

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophilic PEG linker facilitates solubility in biological applications. Propargyl-PEG6-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC molecules) for targeted protein degradation.Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Synthesis

  • Route1

    References

    • Chemical Communications, , # 22 p. 2509 - 2510
  • Route2

    References

    • Chemical and Pharmaceutical Bulletin, , vol. 48, # 8 p. 1230 - 1233
  • Route3
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      849752-40-5
    • ~%
    • In-stock
      Fmoc-Lys-OH|CS-W008176
      105047-45-8
    • N2-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-lysine methyl ester|CS-0998810
      170943-16-5

    References

    • Tetrahedron, , vol. 61, # 9 p. 2493 - 2503

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   101.65
  • LogP   3.1073
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   8

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