tert-Butyl N-(4,4-difluoropiperidin-3-yl)carbamate

Name: tert-Butyl N-(4,4-difluoropiperidin-3-yl)carbamate
Brand: ChemScene
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CAS No. 1052713-53-7
Cat. No. CS-0048071
Molecule weight236.26
Purity≥97%
MDL No.None

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Excepted Quantity	$0.00
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tert-Butyl N-(4,4-difluoropiperidin-3-yl)carbamate|CS-0048071

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General Information

CAS No. 1052713-53-7
Cat. No. CS-0048071
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₈F₂N₂O₂
Molecular Weight 236.26
Synonym(s) Carbamic acid, N-(4,4-difluoro-3-piperidinyl)-, 1,1-dimethylethyl ester
SMILES CC(C)(C)OC(=O)NC1CNCCC1(F)F

Description

tert-Butyl N-(4,4-difluoropiperidin-3-yl)carbamate is a bench-stable, moisture-tolerant building block featuring a sterically hindered piperidine core with two fluorine atoms at the 4-position. This difluoro substitution enhances metabolic stability and modulates electronic properties, enabling efficient incorporation into bioactive molecules. The tert-butyl carbamate group facilitates convenient protection and deprotection under mild acidic conditions, streamlining synthetic access to functionalized piperidines in medicinal chemistry workflows.

Application

tert-Butyl N-(4,4-difluoropiperidin-3-yl)carbamate serves as a stable, bench-ready building block for the synthesis of fluorinated piperidine-based scaffolds. The difluoro substitution enhances metabolic stability and modulates basicity, while the tert-butyl carbamate group provides orthogonal protection for amine functionalities. It facilitates efficient coupling reactions and is compatible with standard deprotection protocols, enabling streamlined access to complex heterocyclic intermediates in medicinal chemistry and API development.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 50.36
LogP 1.5083
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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tert-Butyl N-(4,4-difluoropiperidin-3-yl)carbamate

CAS No. 1052713-53-7

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