Bis(3-ethyl-5-methyl-4-maleimidophenyl)methane

Name: Bis(3-ethyl-5-methyl-4-maleimidophenyl)methane
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CAS No. 105391-33-1
Cat. No. CS-0167819
Purity≥98%
MDL No.MFCD20926792

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FedEx Limited Quantities Ground	$0.00
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Bis(3-ethyl-5-methyl-4-maleimidophenyl)methane|CS-0167819

Structure of 105391-33-1

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Description

Bis(3-ethyl-5-methyl-4-maleimidophenyl)methane features two maleimide groups flanked by ethyl and methyl substituents, enabling efficient bioconjugation under physiological conditions. The sterically tuned aryl framework enhances reactivity with thiols while maintaining stability in aqueous environments. This bifunctional linker facilitates site-specific protein modification and crosslinking applications in biopharmaceutical development.

Application

Bis(3-ethyl-5-methyl-4-maleimidophenyl)methane serves as a versatile bis-electrophilic crosslinking agent, enabling efficient conjugation in polymer chemistry and bioconjugation workflows. The maleimide groups exhibit high reactivity with thiols under physiological conditions, facilitating site-specific labeling. Its rigid biphenyl-like structure enhances thermal stability and provides predictable reaction kinetics, while the ethyl and methyl substituents improve solubility and reduce aggregation during synthesis. Ideal for constructing defined macromolecular architectures and functional materials.

General Information

CAS No. 105391-33-1
Cat. No. CS-0167819
Purity ≥98%
MDL No. MFCD20926792
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₇H₂₆N₂O₄
Molecular Weight 442.51
Synonym(s) Methylenebis(3-ethyl-5-methyl-4-maleimidobenzene)
SMILES O=C1C=CC(N1C2=C(CC)C=C(CC3=CC(CC)=C(N4C(C=CC4=O)=O)C(C)=C3)C=C2C)=O

Computational Chemistry Data

TPSA 74.76
LogP 3.87784
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 6

Safety Information

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GHS Pictogram :	GHS No : GHS08,GHS09
Signal Word : Danger	UN#: 3077
Class : 9	Packing Group : Ⅲ
Hazard Statements : H319-H372-H400
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Bis(3-ethyl-5-methyl-4-maleimidophenyl)methane

CAS No. 105391-33-1

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