2-Chloro-4-fluoronicotinonitrile

Name: 2-Chloro-4-fluoronicotinonitrile
Brand: ChemScene
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CAS No. 1054552-27-0
Cat. No. CS-W021652
Purity≥98%
MDL No.MFCD27996745

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-4-fluoronicotinonitrile|CS-W021652

Structure of 1054552-27-0

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Description

2-Chloro-4-fluoronicotinonitrile features a strategically positioned nitrile group flanked by chlorine and fluorine substituents on a pyridine ring, delivering enhanced electron-withdrawing character. This configuration enables efficient incorporation into advanced synthetic intermediates for pharmaceuticals and agrochemicals, particularly in transition-metal-catalyzed coupling reactions where controlled reactivity and stability are critical.

Application

2-Chloro-4-fluoronicotinonitrile serves as a versatile building block in the synthesis of heterocyclic scaffolds, particularly for pharmaceutical intermediates. Its ortho-halogenated nitrile functionality enables direct coupling reactions via palladium-catalyzed cross-coupling and nucleophilic substitution. The molecule exhibits good bench stability and facilitates efficient functionalization under standard reaction conditions, making it valuable for rapid diversification in medicinal chemistry workflows.

General Information

CAS No. 1054552-27-0
Cat. No. CS-W021652
Purity ≥98%
MDL No. MFCD27996745
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₂ClFN₂
Molecular Weight 156.55
Synonym(s) None
SMILES N#CC1=C(Cl)N=CC=C1F

Computational Chemistry Data

TPSA 36.68
LogP 1.74578
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Cyanide/Nitrile

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-4-fluoronicotinonitrile

CAS No. 1054552-27-0

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