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N3-PEG3-CH2CH2COOH

  • CAS No. 1056024-94-2

  • Cat. No. CS-0022131
  • Molecule weight247.25
  • Purity≥98%
  • MDL No.MFCD23726617

*For research and further manufacturing use only, not for direct human use.

N3-PEG3-CH2CH2COOH|CS-0022131

Structure of 1056024-94-2

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General Information

  • CAS No. 1056024-94-2
  • Cat. No. CS-0022131
  • Purity ≥98%
  • MDL No. MFCD23726617
  • Storage -20°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₇N₃O₅
  • Molecular Weight 247.25
  • Synonym(s) None
  • SMILES O=C(O)CCOCCOCCOCCN=[N+]=[N-]

Description

N3-PEG3-CH2CH2COOH features a triazole-linked PEG3 spacer terminating in a carboxylic acid group, enabling site-specific conjugation via amine coupling. This bifunctional reagent combines enhanced stability with efficient bioconjugation, ideal for labeling proteins, peptides, or biomolecules under physiological conditions.

Application

N3-PEG3-CH2CH2COOH serves as a versatile bifunctional linker for bioconjugation and peptide synthesis, combining the robustness of a triazole-forming azide group with a C-terminal carboxylic acid for amide bond formation. The three-ethylene glycol spacer enhances solubility and reduces non-specific binding, while the aliphatic tether ensures minimal steric interference. This reagent enables efficient site-specific conjugation in aqueous environments, facilitating the construction of protein-drug conjugates, PEGylated peptides, and functionalized biomaterials.

Safety Information

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GHS Pictogram : N/A
GHS No : N/A
Signal Word : N/A
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

  • TPSA   113.75
  • LogP   0.8212
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   12

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