2,6-Dichloropyridine-4-sulfonyl chloride

Name: 2,6-Dichloropyridine-4-sulfonyl chloride
Brand: ChemScene
Availability: InStock
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CAS No. 1058741-91-5
Cat. No. CS-0188497
Purity≥95%
MDL No.MFCD18411528

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2,6-Dichloropyridine-4-sulfonyl chloride|CS-0188497

Structure of 1058741-91-5

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Description

2,6-Dichloropyridine-4-sulfonyl chloride features a reactive sulfonyl chloride group flanked by two chlorine atoms at the 2 and 6 positions of the pyridine ring. This electron-deficient scaffold enables selective acylation of nucleophiles in synthetic transformations. The molecule exhibits enhanced stability under standard conditions while maintaining high reactivity toward amines and alcohols, facilitating efficient incorporation into functionalized heterocycles and bioactive intermediates.

Application

2,6-Dichloropyridine-4-sulfonyl chloride serves as a versatile building block for sulfonamide synthesis, enabling efficient introduction of the pyridine-4-sulfonyl motif into pharmaceutical and agrochemical scaffolds. Its reactivity is well-documented in standard coupling protocols, with the sulfonyl chloride group readily reacting with amines under mild conditions to form stable sulfonamide linkages. The dichloro substitution pattern enhances electrophilicity at the sulfonyl center while maintaining bench stability and ease of purification, making it suitable for scalable, high-yield transformations in medicinal chemistry workflows.

General Information

CAS No. 1058741-91-5
Cat. No. CS-0188497
Purity ≥95%
MDL No. MFCD18411528
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₂Cl₃NO₂S
Molecular Weight 246.50
Synonym(s) 2,6-dichloropyridine-4-sulfonyl chloride(WX192261)
SMILES S(C1=CC(Cl)=NC(=C1)Cl)(=O)(=O)Cl

Computational Chemistry Data

TPSA 47.03
LogP 2.3159
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS05,GHS07
Signal Word : Danger	UN#: 3261
Class : 8	Packing Group : Ⅲ
Hazard Statements : H302-H314-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P312-P330-P363-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2,6-Dichloropyridine-4-sulfonyl chloride

CAS No. 1058741-91-5

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