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CS-W001157 4
Total: USD 88.00

1-(5-Bromo-2-chlorophenyl)ethanone

  • CAS No. 105884-19-3

  • Cat. No. CS-0041764
  • Molecule weightNone
  • Purity≥97%
  • MDL No.MFCD02683851

*For research and further manufacturing use only, not for direct human use.

1-(5-Bromo-2-chlorophenyl)ethanone|CS-0041764

Structure of 105884-19-3

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General Information

  • CAS No. 105884-19-3
  • Cat. No. CS-0041764
  • Purity ≥97%
  • MDL No. MFCD02683851
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆BrClO
  • Molecular Weight None
  • Synonym(s) 5-Bromo-2-Chloroacetophenone
  • SMILES CC(=O)C1=C(Cl)C=CC(Br)=C1

Description

1-(5-Bromo-2-chlorophenyl)ethanone features a brominated and chlorinated aromatic core paired with a reactive ketone group, enabling direct incorporation into cross-coupling reactions. This bench-stable compound serves as a key intermediate for synthesizing bioactive molecules in medicinal chemistry and materials science.

Application

1-(5-Bromo-2-chlorophenyl)ethanone serves as a versatile building block in medicinal chemistry and heterocyclic synthesis, enabling efficient construction of biologically relevant scaffolds. Its bromo and chloro substituents provide orthogonal handles for palladium-catalyzed cross-coupling reactions, while the acetyl group facilitates nucleophilic addition and condensation processes. The compound exhibits excellent bench stability and is compatible with standard purification methods, making it well-suited for scalable synthesis workflows.

Synthesis

  • Route1
    • 1-(5-Bromo-2-chlorophenyl)ethan-1-ol|CS-1259370
      749932-77-2
    • ~84%
    • In-stock
      1-(5-Bromo-2-chlorophenyl)ethanone|CS-0041764
      105884-19-3

    References

    • WO2004/74270 A2, ; Page 363-364 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   3.3051
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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