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Structure of 1060805-95-9
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4-Chloro-6-methylnicotinic acid features a chlorine substituent at the 4-position and a methyl group at the 6-position of the nicotinic acid scaffold. This electron-deficient heterocycle integrates readily into pharmaceutical intermediates, offering enhanced metabolic stability and tailored solubility for synthetic applications in medicinal chemistry workflows.
4-Chloro-6-methylnicotinic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation into heterocyclic scaffolds via coupling and cyclization reactions. Its ortho-chloro and meta-methyl substituents provide controlled reactivity for palladium-catalyzed cross-couplings and functional group manipulations, while the carboxylic acid facilitates amide formation and derivatization. The compound exhibits excellent bench stability and is compatible with standard purification methods, making it well-suited for iterative synthesis campaigns in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: