Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2-(Trifluoromethyl)pyridin-3-ol

  • CAS No. 1063697-17-5

  • Cat. No. CS-0128592
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(Trifluoromethyl)pyridin-3-ol|CS-0128592

Structure of 1063697-17-5

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 1063697-17-5
  • Cat. No. CS-0128592
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄F₃NO
  • Molecular Weight 163.10
  • Synonym(s) 2-(TRIFLUOROMETHYL)-3-HYDROXYPYRIDINE
  • SMILES OC1=CC=CN=C1C(F)(F)F

Description

2-(Trifluoromethyl)pyridin-3-ol features a trifluoromethyl group at the 2-position and a hydroxyl moiety at the 3-position of the pyridine ring, creating a uniquely electron-deficient heteroaromatic scaffold. This configuration enhances its utility in transition metal-catalyzed coupling reactions and as a building block in medicinal chemistry. The molecule exhibits bench-stable handling characteristics and moderate solubility in common organic solvents.

Application

2-(Trifluoromethyl)pyridin-3-ol serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated heterocyclic scaffolds. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the phenolic hydroxyl offers direct functionalization potential. The compound exhibits bench stability and facilitates coupling reactions with aryl halides, sulfonates, and electrophiles under standard catalytic conditions. It functions effectively in Suzuki-Miyaura, Ullmann, and direct arylation protocols, supporting rapid diversification in drug discovery campaigns.

Synthesis

  • Route1
    • null|null
      368-48-9
    • ~70%
    • In-stock
      2-(Trifluoromethyl)pyridin-3-ol|CS-0128592
      1063697-17-5

    References

    • Ma, Yongmin; Roy, Sourav; Kong, Xiaole; Chen, Yulin; Liu, Dingyong; Hider, Robert C. Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2185 - 2195
  • Route2
    • In-stock
      2-Iodo-3-pyridinol|CS-D1763
      40263-57-8
    • null|null
      1514-87-0
    • ~%
    • In-stock
      2-(Trifluoromethyl)pyridin-3-ol|CS-0128592
      1063697-17-5

    References

    • BOEHRINGER INGELHEIM INTERNATIONAL GmbH; STAMMERS, Timothy; BARBEAU, Xavier; BEAULIEU, Pierre; BERTRAND-LAPERLE, Megan; BROCHU, Christian; EDWARDS, Paul, J.; FORGIONE, Pasquale; GODBOUT, Cedrickx; HUCKE, Oliver; JOLY, Marc-Andre; LANDRY, Serge; LEPAGE, Olivier; NAUD, Julie; PESANT, Marc; POIRIER, Martin; POIRIER, Maude; THAVONEKHAM, Bounkham Patent: WO2011/32277 A1, 2011 ; Location in patent: Page/Page column 46 ; WO 2011/032277 A1
  • Route3
    • In-stock
      3-Hydroxypyridine|CS-W009147
      109-00-2
    • null|null
      2314-97-8
    • ~43%
    • In-stock
      2-(Trifluoromethyl)pyridin-3-ol|CS-0128592
      1063697-17-5

    References

    • Kino, Tatsuhito; Nagase, Yu; Ohtsuka, Yuhki; Yamamoto, Kyoko; Uraguchi, Daisuke; Tokuhisa, Kenji; Yamakawa, Tetsu Journal of Fluorine Chemistry, 2010 , vol. 131, # 1 p. 98 - 105

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.806
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 2-(Trifluoromethyl)pyridin-3-ol sigma2-(Trifluoromethyl)pyridin-3-ol manufacturer2-(Trifluoromethyl)pyridin-3-ol price2-(Trifluoromethyl)pyridin-3-ol structure2-(Trifluoromethyl)pyridin-3-ol SDSbuy 2-(Trifluoromethyl)pyridin-3-ol2-(Trifluoromethyl)pyridin-3-ol supplier2-(Trifluoromethyl)pyridin-3-ol uses2-(Trifluoromethyl)pyridin-3-ol molecular weightprice of 2-(Trifluoromethyl)pyridin-3-ol2-(Trifluoromethyl)pyridin-3-ol chemical name formula of 2-(Trifluoromethyl)pyridin-3-ol
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label