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CS-W001157 4
Total: USD 88.00

2,4-Dichloro-5,7-dihydrofuro[3,4-b]pyridine

  • CAS No. 1086321-79-0

  • Cat. No. CS-0470393
  • Purity≥95%
  • MDL No.MFCD31728298

*For research and further manufacturing use only, not for direct human use.

2,4-Dichloro-5,7-dihydrofuro[3,4-b]pyridine|CS-0470393

Structure of 1086321-79-0

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General Information

  • CAS No. 1086321-79-0
  • Cat. No. CS-0470393
  • Purity ≥95%
  • MDL No. MFCD31728298
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅Cl₂NO
  • Molecular Weight 190.03
  • Synonym(s) None
  • SMILES ClC1=NC2=C(COC2)C(Cl)=C1

Description

2,4-Dichloro-5,7-dihydrofuro[3,4-b]pyridine is a heterocyclic scaffold featuring a fused furan-pyridine core with two chlorine substituents. This electron-deficient system enables efficient coupling in transition-metal-catalyzed reactions. The dihydrofuran ring maintains conformational rigidity while offering tunable reactivity for synthetic and medicinal chemistry applications.

Application

2,4-Dichloro-5,7-dihydrofuro[3,4-b]pyridine serves as a versatile building block for heterocyclic synthesis, enabling efficient access to fused pyridine-furan scaffolds via cross-coupling and cyclization reactions. The dichloro substitution pattern facilitates selective functionalization, while the dihydrofuro core offers enhanced bench stability and compatibility with standard synthetic protocols. Its well-defined reactivity profile supports use in medicinal chemistry campaigns targeting kinase inhibitors and other bioactive molecules.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   2.4186
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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