5-Chloro-2-methylthiazolo[5,4-b]pyridine

Name: 5-Chloro-2-methylthiazolo[5,4-b]pyridine
Brand: ChemScene
Availability: InStock
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CAS No. 109202-21-3
Cat. No. CS-0460458
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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5-Chloro-2-methylthiazolo[5,4-b]pyridine|CS-0460458

Structure of 109202-21-3

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Description

5-Chloro-2-methylthiazolo[5,4-b]pyridine features a fused thiazole-pyridine core with strategic chlorine and methyl substitutions, enabling enhanced reactivity in cross-coupling transformations. This electron-deficient heterocycle serves as a robust scaffold for pharmaceutical intermediates, offering improved stability and solubility under standard conditions.

Application

5-Chloro-2-methylthiazolo[5,4-b]pyridine serves as a versatile heterocyclic building block for medicinal chemistry and process development. Its chlorinated thiazole-pyridine fusion enables direct cross-coupling reactions and nucleophilic substitution, facilitating rapid diversification of API scaffolds. The methyl group provides a handle for further functionalization, while the compound exhibits excellent bench stability and compatibility with standard synthetic workflows.

General Information

CAS No. 109202-21-3
Cat. No. CS-0460458
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₅ClN₂S
Molecular Weight 184.65
Synonym(s) 2-methyl-6-chloro-7-azabenzothiazole
SMILES ClC1=NC2=C(C=C1)N=C(C)S2

Computational Chemistry Data

TPSA 25.78
LogP 2.65312
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Thiazole compounds

Key Words

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5-Chloro-2-methylthiazolo[5,4-b]pyridine

CAS No. 109202-21-3

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