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CS-W001157 4
Total: USD 88.00

5-Chloropyrazolo[1,5-a]pyridine

  • CAS No. 1101120-47-1

  • Cat. No. CS-0132671
  • Molecule weight152.58
  • Purity≥98%
  • MDL No.MFCD21603615

*For research and further manufacturing use only, not for direct human use.

5-Chloropyrazolo[1,5-a]pyridine|CS-0132671

Structure of 1101120-47-1

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General Information

  • CAS No. 1101120-47-1
  • Cat. No. CS-0132671
  • Purity ≥98%
  • MDL No. MFCD21603615
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅ClN₂
  • Molecular Weight 152.58
  • Synonym(s) None
  • SMILES ClC1=CC2=CC=NN2C=C1

Description

5-Chloropyrazolo[1,5-a]pyridine is a heterocyclic scaffold featuring a chlorinated pyrazolo[1,5-a]pyridine core, offering enhanced electron-deficiency and stability for use in medicinal chemistry. This rigid, planar structure facilitates π-stacking interactions and integrates readily into kinase inhibitors, fluorescent probes, and bioactive small molecules.

Application

5-Chloropyrazolo[1,5-a]pyridine serves as a versatile heterocyclic building block for medicinal chemistry and materials science applications. Its electron-deficient pyrazolopyridine core enables efficient Suzuki-Miyaura and Buchwald-Hartwig coupling reactions, facilitating the construction of complex biaryl and arylamine architectures. The chlorine atom provides a reliable handle for palladium-catalyzed transformations, while the scaffold exhibits excellent bench stability and compatibility with common protecting groups, making it well-suited for iterative synthesis and scale-up.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.3
  • LogP   1.9877
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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