Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

Exatecan Intermediate 1

  • CAS No. 110351-94-5

  • Cat. No. CS-B1681
  • Purity≥98%
  • MDL No.MFCD17011873

*For research and further manufacturing use only, not for direct human use.

Exatecan Intermediate 1|CS-B1681

Structure of 110351-94-5

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 110351-94-5
  • Cat. No. CS-B1681
  • Purity ≥98%
  • MDL No. MFCD17011873
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₃NO₅
  • Molecular Weight None
  • Synonym(s) (S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
  • SMILES O=C1[C@](O)(CC)C(C=C23)=C(CO1)C(N3CCC2=O)=O

Description

Exatecan Intermediate 1 features a sterically hindered pyrrolidine core paired with a reactive trifluoromethyl ketone moiety, enabling selective coupling in late-stage functionalization. This bench-stable scaffold integrates seamlessly into complex molecular architectures under standard conditions.

Application

Exatecan Intermediate 1 serves as a key building block in the synthesis of exatecan-based anticancer agents, enabling efficient construction of the core indoline scaffold. Its well-defined reactivity profile facilitates selective functionalization under mild conditions, with demonstrated compatibility across standard coupling and cyclization protocols. Bench-stable and readily purified by chromatography, it supports scalable synthesis and integration into complex molecular architectures relevant to medicinal chemistry campaigns.

Synthesis

  • Route1
    • null|null
      183434-04-0
    • ~96%
    • In-stock
      Exatecan Intermediate 1|CS-B1681
      110351-94-5

    References

    • Journal of Organic Chemistry, , vol. 62, # 19 p. 6588 - 6597
  • Route2

    References

    • Tetrahedron Asymmetry, , vol. 6, # 6 p. 1245 - 1248
  • Route3
    • null|null
      165674-36-2
    • ~99%
    • In-stock
      Exatecan Intermediate 1|CS-B1681
      110351-94-5

    References

    • Tetrahedron Asymmetry, , vol. 6, # 6 p. 1245 - 1248

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P264-P270-P280-P301+P310-P305+P351+P338-P330-P337+P313-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   85.6
  • LogP   0.0891
  • H_Acceptors   6
  • H_Donors   1
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • Exatecan Intermediate 1 sigmaExatecan Intermediate 1 manufacturerExatecan Intermediate 1 priceExatecan Intermediate 1 structureExatecan Intermediate 1 SDSbuy Exatecan Intermediate 1Exatecan Intermediate 1 supplierExatecan Intermediate 1 usesExatecan Intermediate 1 molecular weightprice of Exatecan Intermediate 1Exatecan Intermediate 1 chemical name formula of Exatecan Intermediate 1
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label