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CS-W001157 4
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3-(2-Fluorophenyl)piperidine hydrochloride

  • CAS No. 1106940-90-2

  • Cat. No. CS-0217446
  • Molecule weight215.69
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-(2-Fluorophenyl)piperidine hydrochloride|CS-0217446

Structure of 1106940-90-2

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General Information

  • CAS No. 1106940-90-2
  • Cat. No. CS-0217446
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₅ClFN
  • Molecular Weight 215.69
  • Synonym(s) None
  • SMILES C1=CC=C(C(=C1)C2CCCNC2)F.Cl

Description

3-(2-Fluorophenyl)piperidine hydrochloride is a bench-stable, moisture-tolerant heterocyclic compound featuring a fluorinated aromatic ring fused to a piperidine core. This structure delivers enhanced lipophilicity and metabolic stability, enabling efficient integration into CNS-targeted drug discovery scaffolds.

Application

3-(2-Fluorophenyl)piperidine hydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive scaffolds through standard amine functionalization and coupling reactions. Its bench-stable hydrochloride salt form enhances handling and purification, while the ortho-fluorinated aryl group provides favorable electronic and steric properties for target engagement. Functions effectively in Suzuki-Miyaura couplings and reductive aminations, supporting scalable synthesis of CNS-targeted compounds.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   2.7145
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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