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CS-W001157 4
Total: USD 88.00

DMT-2'O-Methyl-rU Phosphoramidite

  • CAS No. 110764-79-9

  • Cat. No. CS-0154033
  • Purity≥95%
  • MDL No.MFCD00792626

*For research and further manufacturing use only, not for direct human use.

DMT-2'O-Methyl-rU Phosphoramidite|CS-0154033

Structure of 110764-79-9

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General Information

  • CAS No. 110764-79-9
  • Cat. No. CS-0154033
  • Purity ≥95%
  • MDL No. MFCD00792626
  • Storage -20°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄₀H₄₉N₄O₉P
  • Molecular Weight 760.81
  • Synonym(s) 2'-O-Me-U Phosphoramidite
  • SMILES COC(C=C1)=CC=C1C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)OC[C@@H]4[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](OC)[C@H](N5C(NC(C=C5)=O)=O)O4

Description

Pyridoxine hydrochloride has been used:as a vitamin supplement in the basal medium for the cultivation of Bacillus mojavensis and Bacillus subtilis strainsas a supplement in pre-conditioning medium/MS salts to initiate somatic embryogenesis induction of Coffea canephora seedsfor oral administration in piglets to study its effect on the development of homocysteinemia

Application

DMT-2'O-Methyl-rU Phosphoramidite serves as a key building block for the site-specific incorporation of 2'-O-methyluridine residues into oligonucleotides during solid-phase synthesis. Its DMT protection ensures easy purification and monitoring, while the 2'-O-methyl modification enhances nuclease resistance and binding affinity. The phosphoramidite functionality enables efficient coupling under standard protocols, offering high yield and compatibility with automated synthesizers.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P233-P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   146.5
  • LogP   6.13608
  • H_Acceptors   12
  • H_Donors   1
  • Rotatable_Bonds   18

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