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Structure of 1113-59-3
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3-Bromopyruvic acid is a potent electrophilic metabolite analog featuring a bromine-substituted α-keto acid core. This compound integrates readily into glycolytic pathways, selectively targeting cysteine residues in key metabolic enzymes. Its high reactivity enables efficient inhibition of thiol-dependent dehydrogenases, making it valuable for probing cellular energy metabolism and developing targeted anticancer strategies.
3-Bromopyruvic acid serves as a versatile α-halo ketone building block for nucleophilic substitution and conjugate addition reactions. Its reactive bromine substituent enables efficient functionalization at the C3 position, facilitating access to substituted pyruvates and heterocyclic scaffolds. The compound exhibits sufficient bench stability for handling in standard organic synthesis workflows and is compatible with various protecting group strategies. Functions effectively in Michael additions, halogen-metal exchange, and transition metal-catalyzed coupling protocols.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H314
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Precautionary Statements : P260-P280-P301+P330+P331-P304+P340
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Lot numbers can be found on the outside label of a product: