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CS-W001157 4
Total: USD 88.00

(6-Chloro-5-(trifluoromethyl)pyridin-3-yl)methanol

  • CAS No. 1113049-91-4

  • Cat. No. CS-0186093
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

(6-Chloro-5-(trifluoromethyl)pyridin-3-yl)methanol|CS-0186093

Structure of 1113049-91-4

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Description

This trifluoromethyl-substituted pyridinyl methanol features a reactive alcohol group flanked by electron-withdrawing chlorine and trifluoromethyl moieties, enabling efficient coupling in cross-coupling and functionalization reactions.

Application

(6-Chloro-5-(trifluoromethyl)pyridin-3-yl)methanol serves as a versatile building block in medicinal chemistry, enabling efficient access to functionalized pyridine scaffolds. The pendant alcohol facilitates derivatization via esterification, etherification, or oxidation to aldehyde, while the chloro and trifluoromethyl groups provide orthogonal reactivity for cross-coupling and nucleophilic substitution. Its bench-stable nature and compatibility with standard synthetic protocols make it well-suited for modular synthesis of bioactive compounds.

General Information

  • CAS No. 1113049-91-4
  • Cat. No. CS-0186093
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅ClF₃NO
  • Molecular Weight 211.57
  • Synonym(s) 2-Chloro-3-(trifluoromethyl)-5-hydroxymethylpyridine
  • SMILES C1=C(C=NC(=C1C(F)(F)F)Cl)CO

Computational Chemistry Data

  • TPSA   33.12
  • LogP   2.2461
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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