Ethyl 3-bromo-2,2-difluoropropanoate

Name: Ethyl 3-bromo-2,2-difluoropropanoate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

SDS

CAS No. 111773-24-1
Cat. No. CS-0235495
Purity≥97%
MDL No.MFCD15144891

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Ethyl 3-bromo-2,2-difluoropropanoate|CS-0235495

Structure of 111773-24-1

Size

Price

Quantity

* Please select Quantity before adding items.

Recommended Products

In-stock

1H-Pyrrole-3-carbonitrile

CAS No. :7126-38-7

Cat. No. :CS-W006281

Purity:≥98%

* This product is not sold in the region.
In-stock

tert-Butyl 2-bromo-7-azaspiro[3.5]nonane-7-carboxylate

CAS No. :1225276-07-2

Cat. No. :CS-0048426

Purity:≥97%

* This product is not sold in the region.
In-stock

6-Bromophthalazinone

CAS No. :75884-70-7

Cat. No. :CS-W008890

Purity:≥95%

* This product is not sold in the region.
In-stock

3-Dimethylaminophenylboronic acid

CAS No. :178752-79-9

Cat. No. :CS-W009263

Purity:≥95%

* This product is not sold in the region.
In-stock

6-Methoxypyridazine-3-carboxylic acid

CAS No. :56434-28-7

Cat. No. :CS-0050177

Purity:≥96%

* This product is not sold in the region.
In-stock

Methyl 3-methoxytetrafluoropropionate

CAS No. :755-73-7

Cat. No. :CS-0121443

Purity:≥97%

* This product is not sold in the region.
In-stock

Ethyl nitroacetate

CAS No. :626-35-7

Cat. No. :CS-0000037

Purity:≥96%

* This product is not sold in the region.
In-stock

Eosin adsorption indicator

CAS No. :15086-94-9

Cat. No. :CS-0169100

Purity:IND

* This product is not sold in the region.

General Information

CAS No. 111773-24-1
Cat. No. CS-0235495
Purity ≥97%
MDL No. MFCD15144891
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₇BrF₂O₂
Molecular Weight 217.01
Synonym(s) Ethyl 3-bromo-2,2-difluoropropionate
SMILES CCOC(=O)C(CBr)(F)F

Description

Ethyl 3-bromo-2,2-difluoropropanoate features a trifluoromethyl-like electronic profile due to the geminal difluoro substitution, enabling unique reactivity in fluorinated building block synthesis. The α-bromo ester moiety facilitates nucleophilic displacement and cross-coupling transformations under mild conditions. This bench-stable reagent integrates readily into complex molecular architectures requiring stereocontrolled fluorination or C–C bond formation.

Application

Ethyl 3-bromo-2,2-difluoropropanoate serves as a versatile building block for fluorinated synthetic intermediates, enabling efficient construction of difluoromethyl-containing motifs via nucleophilic substitution or elimination reactions. Its stability under standard bench conditions and compatibility with palladium-catalyzed cross-couplings facilitate the synthesis of complex fluorinated scaffolds relevant to medicinal chemistry and agrochemical development.

Synthesis

Route1
- 765-63-9
- 60-29-7
- ~80%
- In-stock
  
  111773-24-1
References
- Yamada, Shigeyuki; Kato, Masahiro; Komori, Yudai; Konno, Tsutomu; Ishihara, Takashi Organic and Biomolecular Chemistry, 2011 , vol. 9, # 15 p. 5493 - 5502
Route2
- 70-23-5
- ~%
- In-stock
  
  111773-24-1
References
- Joyeau, Roger; Molines, Huguette; Labia, Roger; Wakselman, Michel Journal of Medicinal Chemistry, 1988 , vol. 31, # 2 p. 370 - 374
Route3
- 64-17-5
- 61444-65-3
- ~75%
- In-stock
  
  111773-24-1
References
- Gassen, K.-R.; Bielefeldt, D.; Marhold, A.; Andres P. Journal of Fluorine Chemistry, 1991 , vol. 55, # 2 p. 149 - 162

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS02,GHS06
Signal Word : Danger	UN#: 3272
Class : 3	Packing Group : Ⅲ
Hazard Statements : H226-H301-H315-H319-H332-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

SDS
COA

Computational Chemistry Data

TPSA 26.3
LogP 1.5797
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 3

Similar Products

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Bromide

Building Blocks Functional Group Ester

Key Words

Ethyl 3-bromo-2,2-difluoropropanoate sigmaEthyl 3-bromo-2,2-difluoropropanoate manufacturerEthyl 3-bromo-2,2-difluoropropanoate priceEthyl 3-bromo-2,2-difluoropropanoate structureEthyl 3-bromo-2,2-difluoropropanoate SDSbuy Ethyl 3-bromo-2,2-difluoropropanoateEthyl 3-bromo-2,2-difluoropropanoate supplierEthyl 3-bromo-2,2-difluoropropanoate usesEthyl 3-bromo-2,2-difluoropropanoate molecular weightprice of Ethyl 3-bromo-2,2-difluoropropanoateEthyl 3-bromo-2,2-difluoropropanoate chemical name formula of Ethyl 3-bromo-2,2-difluoropropanoate

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

Ethyl 3-bromo-2,2-difluoropropanoate

CAS No. 111773-24-1

Recommended Products

General Information

Description

Application

Synthesis

References

References

References

Safety Information

Quality Control

Computational Chemistry Data

Similar Products

Other Classifications

Recently Viewed Products

Key Words