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Ethyl 3-bromo-2,2-difluoropropanoate

  • CAS No. 111773-24-1

  • Cat. No. CS-0235495
  • Purity≥97%
  • MDL No.MFCD15144891
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Ethyl 3-bromo-2,2-difluoropropanoate|CS-0235495

Structure of 111773-24-1

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Description

Ethyl 3-bromo-2,2-difluoropropanoate features a trifluoromethyl-like electronic profile due to the geminal difluoro substitution, enabling unique reactivity in fluorinated building block synthesis. The α-bromo ester moiety facilitates nucleophilic displacement and cross-coupling transformations under mild conditions. This bench-stable reagent integrates readily into complex molecular architectures requiring stereocontrolled fluorination or C–C bond formation.

Application

Ethyl 3-bromo-2,2-difluoropropanoate serves as a versatile building block for fluorinated synthetic intermediates, enabling efficient construction of difluoromethyl-containing motifs via nucleophilic substitution or elimination reactions. Its stability under standard bench conditions and compatibility with palladium-catalyzed cross-couplings facilitate the synthesis of complex fluorinated scaffolds relevant to medicinal chemistry and agrochemical development.

General Information

  • CAS No. 111773-24-1
  • Cat. No. CS-0235495
  • Purity ≥97%
  • MDL No. MFCD15144891
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇BrF₂O₂
  • Molecular Weight 217.01
  • Synonym(s) Ethyl 3-bromo-2,2-difluoropropionate
  • SMILES CCOC(=O)C(CBr)(F)F

Computational Chemistry Data

  • TPSA   26.3
  • LogP   1.5797
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   3

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS06
Signal Word : Danger
UN#: 3272
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226-H301-H315-H319-H332-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P405-P501

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