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Structure of 1121-19-3
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4-Methylpyridin-3-ol features a pyridine ring bearing a methyl group at the 4-position and a hydroxyl substituent at the 3-position, creating a uniquely positioned phenolic function within a nitrogen-heterocyclic framework. This arrangement imparts enhanced solubility in polar solvents and facilitates direct participation in hydrogen bonding networks. The molecule exhibits bench-stable behavior under standard conditions and integrates readily into synthetic pathways requiring electron-rich heterocyclic scaffolds.
4-Methylpyridin-3-ol serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds through electrophilic substitution and transition-metal-catalyzed coupling reactions. Its phenolic hydroxyl group offers direct functionalization potential, while the pyridine nitrogen provides coordination sites for metal catalysts. The methyl substituent enhances metabolic stability and modulates electronic properties, contributing to favorable physicochemical profiles. This compound exhibits bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: