α-Methyl-DL-phenylalanine

Name: α-Methyl-DL-phenylalanine
Brand: ChemScene
Availability: InStock
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CAS No. 1132-26-9
Cat. No. CS-0201627
Purity≥98%
MDL No.MFCD00010512

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 1132-26-9

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Description

α-Methyl-DL-phenylalanine features a methyl-substituted alpha carbon that confers enhanced metabolic stability compared to native phenylalanine. This structural modification resists enzymatic degradation while retaining aromatic side-chain interactions, making it valuable for probing peptide backbone dynamics and designing protease-resistant analogs in medicinal chemistry applications.

Application

α-Methyl-DL-phenylalanine serves as a stable, bench-accessible building block for peptide synthesis and heterocyclic scaffold development. Its side chain functionality enables straightforward incorporation into bioactive molecules, while the α-methyl group enhances metabolic stability and resistance to enzymatic degradation. The compound exhibits good solubility and purification compatibility in standard organic protocols, facilitating its use in medicinal chemistry campaigns targeting CNS-active compounds and peptidomimetics.

General Information

CAS No. 1132-26-9
Cat. No. CS-0201627
Purity ≥98%
MDL No. MFCD00010512
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₃NO₂
Molecular Weight 179.22
Synonym(s) None
SMILES CC(CC1=CC=CC=C1)(C(=O)O)N

Computational Chemistry Data

TPSA 63.32
LogP 1.0311
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 3

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Phenylalanine and derivatives

Chemical Biology Peptide Chemistry Amino Acid Derivatives

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α-Methyl-DL-phenylalanine

CAS No. 1132-26-9

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