(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane

Name: (1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 113451-59-5
Cat. No. CS-W004668
Molecule weight198.26
Purity≥97%
MDL No.MFCD01569250

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane|CS-W004668

Structure of 113451-59-5

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 113451-59-5
Cat. No. CS-W004668
Purity ≥97%
MDL No. MFCD01569250
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₈N₂O₂
Molecular Weight 198.26
Synonym(s) tert-Butyl (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate
SMILES C(=O)(OC(C)(C)C)N1C[C@H]2NC[C@@H]1C2

Description

(1S,4S)-(-)-2-Boc-2,5-diazabicyclo[2.2.1]heptane may be used in the preparation of 2-boc-5-(4-nitrophenyl)-2,5-diaza-bicyclo[2.2.1]heptane by reacting with p-nitrobenzene.It may also be used to develop:indazolylpyrazolo[1,5-a]pyrimidine analogs based B-Raf inhibitorsCCR2 antagonists42 nicotinic acetylcholine receptor (nAChR) partial agonistsazabicyclic sulfonamide based 11-hydroxysteroid dehydrogenase type 1 (11-HSD1) inhibitors

Application

(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane serves as a conformationally constrained chiral diamine scaffold, enabling stereoselective transformations in asymmetric synthesis. The Boc-protected amine functionality offers stability and orthogonal deprotection, facilitating sequential functionalization. Its rigid bicyclic structure imparts defined spatial orientation, enhancing diastereoselectivity in catalytic reactions and serving as a key building block for bioactive heterocycles and ligand development.

Synthesis

Route1
- 113451-54-0
- ~99%
- In-stock
  
  113451-59-5
References
- Rosen, Terry; Lico, Isabella M.; Chu, Daniel T. W. Journal of Organic Chemistry, 1988 , vol. 53, # 7 p. 1580 - 1582
Route2
- 132666-68-3
- ~76%
- In-stock
  
  113451-59-5
References
- Huang, Xiaoguang; Chen, Dongliang; Wu, Ning; Zhang, Aiqin; Jia, Zhenhua; Li, Xingshu Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4130 - 4133
Route3
- In-stock
  
  40216-83-9
- ~%
- In-stock
  
  113451-59-5
References
- Tetrahedron Letters, , vol. 54, # 39 p. 5345 - 5347

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 41.57
LogP 0.9676
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Building Blocks Skeleton Bridge Rings compounds Other bridge ring compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

113451-59-5 sigma113451-59-5 manufacturer113451-59-5 price113451-59-5 structure113451-59-5 SDSbuy 113451-59-5113451-59-5 supplier113451-59-5 uses113451-59-5 molecular weightprice of 113451-59-5113451-59-5 chemical name formula of 113451-59-5

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane

CAS No. 113451-59-5

Recommended Products

General Information

Description

Application

Synthesis

References

References

References

Safety Information

Quality Control

Computational Chemistry Data

Similar Products

Other Classifications

Recently Viewed Products

Key Words