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CS-W001157 4
Total: USD 88.00

Temozolomide acid

  • CAS No. 113942-30-6

  • Cat. No. CS-W019112
  • Purity≥98%
  • MDL No.MFCD12032160
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Temozolomide acid|CS-W019112

Structure of 113942-30-6

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Description

Temozolomide acid exhibits enhanced solubility and stability under physiological conditions compared to its parent compound. This derivative integrates readily into synthetic workflows requiring a reactive carboxylic acid handle, enabling direct conjugation or derivatization in medicinal chemistry campaigns targeting DNA alkylating agents.

Application

Temozolomide acid serves as a key synthetic intermediate in the preparation of temozolomide, a clinically used alkylating agent for glioblastoma and other malignancies. It functions as a stable precursor to the active imidazotetrazine moiety, enabling controlled delivery of methylating species under physiological conditions. The compound exhibits good bench stability and facilitates straightforward derivatization via amide coupling or esterification, supporting scalable synthesis and purification workflows essential for pharmaceutical development.

General Information

  • CAS No. 113942-30-6
  • Cat. No. CS-W019112
  • Purity ≥98%
  • MDL No. MFCD12032160
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅N₅O₃
  • Molecular Weight None
  • Synonym(s) None
  • SMILES CN1N=NC2=C(N=CN2C1=O)C(O)=O

Computational Chemistry Data

  • TPSA   102.38
  • LogP   -1.4788
  • H_Acceptors   7
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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