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Structure of 113942-30-6
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Temozolomide acid exhibits enhanced solubility and stability under physiological conditions compared to its parent compound. This derivative integrates readily into synthetic workflows requiring a reactive carboxylic acid handle, enabling direct conjugation or derivatization in medicinal chemistry campaigns targeting DNA alkylating agents.
Temozolomide acid serves as a key synthetic intermediate in the preparation of temozolomide, a clinically used alkylating agent for glioblastoma and other malignancies. It functions as a stable precursor to the active imidazotetrazine moiety, enabling controlled delivery of methylating species under physiological conditions. The compound exhibits good bench stability and facilitates straightforward derivatization via amide coupling or esterification, supporting scalable synthesis and purification workflows essential for pharmaceutical development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: