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*For research and further manufacturing use only, not for direct human use.
Structure of 1146629-74-4
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This chiral pyrrolidine scaffold features a sterically hindered silyl-protected hydroxymethyl group at the 2-position, enabling selective functionalization in asymmetric synthesis. The bis(trifluoromethyl)phenyl substituents confer enhanced electron-withdrawing character and improved solubility in organic media, facilitating use under standard bench conditions.
(2R)-2-[Bis[3,5-bis(trifluoromethyl)phenyl]-[(tert-butyldimethylsilyl)oxy]methyl]pyrrolidine serves as a robust chiral auxiliary in asymmetric synthesis, leveraging its sterically encumbered pyrrolidine core and silyl-protected hydroxymethyl group. The trifluoromethyl-substituted aryl moieties enhance stability and modulate electronic properties, while the tert-butyldimethylsilyl (TBS) ether enables selective deprotection and orthogonal functionalization. This scaffold facilitates stereoselective C–C bond formation and functions reliably in multistep sequences requiring bench-stable, high-purity intermediates for medicinal chemistry and process development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: