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CS-W001157 4
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4-Bromo-3-methoxy-1H-pyrazole

  • CAS No. 1147011-26-4

  • Cat. No. CS-0495715
  • Purity≥95%
  • MDL No.MFCD27665103

*For research and further manufacturing use only, not for direct human use.

4-Bromo-3-methoxy-1H-pyrazole|CS-0495715

Structure of 1147011-26-4

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General Information

  • CAS No. 1147011-26-4
  • Cat. No. CS-0495715
  • Purity ≥95%
  • MDL No. MFCD27665103
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅BrN₂O
  • Molecular Weight 177.00
  • Synonym(s) 4-Bromo-5-methoxy-1H-pyrazole
  • SMILES COC1C(Br)=CNN=1

Description

4-Bromo-3-methoxy-1H-pyrazole features a brominated pyrazole core with a methoxy group at the 3-position, enabling selective functionalization in cross-coupling reactions. This bench-stable heterocycle integrates readily into complex scaffolds for medicinal chemistry and materials science applications.

Application

4-Bromo-3-methoxy-1H-pyrazole serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-defined halogen reactivity. The methoxy group enhances solubility and modulates electronic properties, while the pyrazole core provides stability under standard synthetic conditions. Its bench-stable nature and compatibility with diverse functional groups facilitate efficient incorporation into heterocyclic scaffolds for API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   37.91
  • LogP   1.1808
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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