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CS-W001157 4
Total: USD 88.00

1-Methyl-1H-indazole-6-boronic acid

  • CAS No. 1150114-80-9

  • Cat. No. CS-W000859
  • Purity≥98%
  • MDL No.MFCD09870053

*For research and further manufacturing use only, not for direct human use.

1-Methyl-1H-indazole-6-boronic acid|CS-W000859

Structure of 1150114-80-9

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General Information

  • CAS No. 1150114-80-9
  • Cat. No. CS-W000859
  • Purity ≥98%
  • MDL No. MFCD09870053
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉BN₂O₂
  • Molecular Weight 175.98
  • Synonym(s) (1-Methyl-1H-indazol-6-yl)boronic acid
  • SMILES OB(c1ccc2c(c1)n(C)nc2)O

Description

1-Methyl-1H-indazole-6-boronic acid features a boronic acid group positioned at the 6-position of a methyl-substituted indazole core. This configuration enables direct incorporation into Suzuki-Miyaura cross-coupling reactions under standard conditions. The electron-rich heterocyclic scaffold enhances reactivity and stability, while the methyl group improves solubility and handling. This compound serves as a key building block for bioactive molecules in medicinal chemistry.

Application

1-Methyl-1H-indazole-6-boronic acid serves as a versatile building block for Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl scaffolds prevalent in pharmaceutical and agrochemical research. The boronic acid moiety exhibits excellent bench stability and tolerates a range of functional groups, facilitating straightforward purification and integration into complex molecular architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   58.28
  • LogP   -0.7469
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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