4-Bromo-1-cyclopropyl-1H-pyrazole

Name: 4-Bromo-1-cyclopropyl-1H-pyrazole
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1151802-23-1
Cat. No. CS-W000378
Purity≥97%
MDL No.MFCD18250639

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4-Bromo-1-cyclopropyl-1H-pyrazole|CS-W000378

Structure of 1151802-23-1

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General Information

CAS No. 1151802-23-1
Cat. No. CS-W000378
Purity ≥97%
MDL No. MFCD18250639
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇BrN₂
Molecular Weight 187.04
Synonym(s) 4-bromo-1-cyclopropylpyrazole
SMILES BrC(C=N1)=CN1C2CC2

Description

4-Bromo-1-cyclopropyl-1H-pyrazole features a brominated pyrazole core with a cyclopropyl substituent at the 1-position, offering enhanced metabolic stability and steric bulk. This scaffold integrates readily into medicinal chemistry libraries, enabling access to bioactive compounds through cross-coupling and functionalization reactions under standard conditions.

Application

4-Bromo-1-cyclopropyl-1H-pyrazole serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its stable bromo functionality. The cyclopropyl group enhances metabolic stability and modulates lipophilicity, while the pyrazole core provides a rigid scaffold for target engagement. Its bench-stable nature and compatibility with standard reaction conditions facilitate efficient synthesis of diverse heterocyclic architectures.

Synthesis

Route1
- In-stock
  
  2075-45-8
- 4333-56-6
- ~69%
- In-stock
  
  1151802-23-1
References
- CROWN BIOSCIENCE INC. (TAICANG); ZHONG, Boyu; SHIH, Chuan; YUAN, Hongbin; ZHOU, Feng Patent: WO2014/32498 A1, 2014 ; Location in patent: Page/Page column 14 ;
Route2
- In-stock
  
  1151814-36-6
- ~%
- In-stock
  
  1151802-23-1
References
- WO2010/141273 A1, ; Page/Page column 53 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 17.82
LogP 1.9805
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Key Words

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4-Bromo-1-cyclopropyl-1H-pyrazole

CAS No. 1151802-23-1

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