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Structure of 115899-39-3
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5-Propargylamino-dCTP integrates a propargylamine handle into the cytidine scaffold, enabling site-specific bioconjugation via copper-catalyzed azide-alkyne cycloaddition. This modified nucleotide incorporates efficiently into DNA during synthesis, offering a robust strategy for labeling oligonucleotides with minimal perturbation to duplex stability.
5-Propargylamino-dCTP serves as a versatile nucleoside triphosphate analog for site-specific incorporation into DNA during enzymatic synthesis. Its propargylamino group enables bioorthogonal conjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC), facilitating downstream labeling, affinity capture, or probe immobilization. The compound exhibits good stability under standard polymerase reaction conditions and supports efficient enzymatic extension, making it suitable for applications in DNA tagging, sequencing, and synthetic biology workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: