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CS-W001157 4
Total: USD 88.00

TLR4-IN-C34-C2-COOH

  • CAS No. 1159408-54-4

  • Cat. No. CS-0137490
  • Purity≥95%
  • MDL No.MFCD30802159
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

TLR4-IN-C34-C2-COOH|CS-0137490

Structure of 1159408-54-4

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Description

TLR4-IN-C34-C2-COOH is a potent, selective inhibitor of Toll-like receptor 4 signaling, designed for precise modulation of innate immune responses. This compound features a carboxylic acid terminus enabling conjugation and bioconjugation applications. Its structure incorporates a hydrophobic core that enhances membrane permeability and target engagement. Bench-stable under standard conditions, it facilitates robust in vitro and cellular assays.

Application

TLR4-IN-C34-C2-COOH serves as a well-characterized Toll-like receptor 4 (TLR4) antagonist scaffold, enabling selective inhibition in innate immune signaling pathways. Its carboxylic acid functionality facilitates conjugation and derivatization for probe development, while the C34-C2 backbone offers enhanced metabolic stability and solubility. Functions effectively in cellular assays to modulate inflammatory responses, making it a practical tool for immunopharmacology research and target validation studies.

General Information

  • CAS No. 1159408-54-4
  • Cat. No. CS-0137490
  • Purity ≥95%
  • MDL No. MFCD30802159
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₉H₂₉NO₁₁
  • Molecular Weight 447.43
  • Synonym(s) None
  • SMILES O=C(O)CCCCO[C@H]1[C@H](NC(C)=O)[C@H]([C@H]([C@@H](COC(C)=O)O1)OC(C)=O)OC(C)=O

Computational Chemistry Data

  • TPSA   163.76
  • LogP   -0.086
  • H_Acceptors   10
  • H_Donors   2
  • Rotatable_Bonds   11

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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