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Structure of 116272-41-4
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4-Bromo-1-fluoro-2-iodobenzene features a trihalogenated aromatic core with distinct electronic and steric profiles. This ortho-iodo-substituted benzene integrates readily into cross-coupling reactions, where the fluorine acts as a traceless directing group. The molecule exhibits enhanced reactivity in palladium-catalyzed transformations due to the synergistic influence of bromine and iodine leaving groups.
4-Bromo-1-fluoro-2-iodobenzene serves as a versatile trihalogenated benzene building block for palladium-catalyzed cross-coupling reactions. Its orthogonal halogen reactivity enables sequential functionalization, with the iodine group typically undergoing rapid coupling followed by bromine or fluoride substitution. The molecule exhibits good bench stability and facilitates efficient access to complex substituted arenes, making it valuable in medicinal chemistry and materials synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: