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Structure of 117358-51-7
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1,3-Difluoro-5-methylbenzene is a fluorinated aromatic compound featuring complementary electron-withdrawing fluorine atoms and a methyl group positioned for steric and electronic modulation. This substitution pattern enables selective functionalization in synthetic routes requiring balanced reactivity and stability under standard conditions.
1,3-Difluoro-5-methylbenzene serves as a valuable building block for fluorinated aromatic scaffolds, enabling direct functionalization at the electron-rich methyl-substituted position. Its orthogonal reactivity profile facilitates palladium-catalyzed cross-couplings and electrophilic substitutions under mild conditions, with the difluoro pattern enhancing metabolic stability in bioactive molecule design. Bench-stable and amenable to purification via standard distillation or chromatography, it functions effectively in medicinal chemistry lead optimization and agrochemical development workflows.
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GHS No : GHS02,GHS08,GHS09
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Signal Word : Danger
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UN#: 1993
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Class : 3
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Packing Group : Ⅱ
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Hazard Statements : H225-H304-H315-H336-H361-H373-H411
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Precautionary Statements : P210-P260-P280-P331
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Lot numbers can be found on the outside label of a product: