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CS-W001157 4
Total: USD 88.00

1,3-Difluoro-5-methylbenzene

  • CAS No. 117358-51-7

  • Cat. No. CS-W013474
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1,3-Difluoro-5-methylbenzene|CS-W013474

Structure of 117358-51-7

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Description

1,3-Difluoro-5-methylbenzene is a fluorinated aromatic compound featuring complementary electron-withdrawing fluorine atoms and a methyl group positioned for steric and electronic modulation. This substitution pattern enables selective functionalization in synthetic routes requiring balanced reactivity and stability under standard conditions.

Application

1,3-Difluoro-5-methylbenzene serves as a valuable building block for fluorinated aromatic scaffolds, enabling direct functionalization at the electron-rich methyl-substituted position. Its orthogonal reactivity profile facilitates palladium-catalyzed cross-couplings and electrophilic substitutions under mild conditions, with the difluoro pattern enhancing metabolic stability in bioactive molecule design. Bench-stable and amenable to purification via standard distillation or chromatography, it functions effectively in medicinal chemistry lead optimization and agrochemical development workflows.

General Information

  • CAS No. 117358-51-7
  • Cat. No. CS-W013474
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆F₂
  • Molecular Weight 128.12
  • Synonym(s) 3,5-Difluorotoluene
  • SMILES CC1=CC(F)=CC(F)=C1

Computational Chemistry Data

  • TPSA   0
  • LogP   2.27322
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS08,GHS09
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅱ
Hazard Statements : H225-H304-H315-H336-H361-H373-H411
Precautionary Statements : P210-P260-P280-P331

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