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Structure of 1174305-81-7
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This difluoromethyl-substituted pyrazole carboxylic acid features a polar, electron-deficient heterocyclic core paired with a moisture-tolerant difluoromethyl group. It integrates readily into bioisosteric replacements and serves as a key scaffold in medicinal chemistry for modulating metabolic stability and membrane permeability.
1-(Difluoromethyl)-1H-pyrazole-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the introduction of a polar, metabolically stable difluoromethyl group adjacent to a pyrazole core. Its carboxylic acid functionality facilitates direct coupling reactions and salt formation, while the difluoromethyl moiety enhances lipophilicity and bioavailability. The compound exhibits good bench stability and compatibility with standard synthetic transformations, making it suitable for the construction of diverse heterocyclic scaffolds and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H320-H335
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Precautionary Statements : P264-P270-P330
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Lot numbers can be found on the outside label of a product: