(R)-3-fluoropyrrolidin-2-one

Name: (R)-3-fluoropyrrolidin-2-one
Brand: ChemScene
Availability: InStock
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CAS No. 1175052-20-6
Cat. No. CS-0500742
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 1175052-20-6

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Description

(R)-3-fluoropyrrolidin-2-one is a stereochemically defined heterocyclic building block featuring a fluorinated pyrrolidinone core. This bench-stable, moisture-tolerant scaffold integrates readily into bioactive molecules, offering enhanced metabolic stability and modulated lipophilicity. Its well-defined chiral center enables precise control in asymmetric synthesis.

Application

(R)-3-Fluoropyrrolidin-2-one serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of fluorinated bioactive molecules. Its stable cyclic lactam structure exhibits favorable functional group tolerance and facilitates stereoselective transformations. The molecule functions effectively in coupling reactions and acts as a key scaffold for peptidomimetics and CNS-targeted therapeutics.

General Information

CAS No. 1175052-20-6
Cat. No. CS-0500742
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₆FNO
Molecular Weight 103.09
Synonym(s) None
SMILES F[C@@H]1CCNC1=O

Computational Chemistry Data

TPSA 29.1
LogP -0.1556
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

Quality Control

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Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-3-fluoropyrrolidin-2-one

CAS No. 1175052-20-6

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