2,4-Dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride

Name: 2,4-Dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1187830-76-7
Cat. No. CS-0052167
Purity≥95%
MDL No.MFCD11518996

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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2,4-Dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride|CS-0052167

Structure of 1187830-76-7

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Description

This bench-stable heterocyclic scaffold features a fused pyridopyrimidine core with strategically positioned chlorine substituents, enabling enhanced electron-withdrawing character and improved metabolic stability. The hydrochloride salt form ensures excellent solubility in aqueous and polar organic media, facilitating efficient incorporation into medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds.

Application

2,4-Dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to pyridopyrimidine scaffolds. Its dichloro substitution pattern facilitates electrophilic functionalization and transition-metal-catalyzed coupling reactions. The hydrochloride salt enhances solubility and stability for handling, supporting reliable performance in multi-step synthesis workflows.

General Information

CAS No. 1187830-76-7
Cat. No. CS-0052167
Purity ≥95%
MDL No. MFCD11518996
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₈Cl₃N₃
Molecular Weight 240.52
Synonym(s) 2,4-dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine,hydrochloride
SMILES ClC1=C2C(CNCC2)=NC(Cl)=N1.[H]Cl

Computational Chemistry Data

TPSA 37.81
LogP 1.8509
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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2,4-Dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride

CAS No. 1187830-76-7

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