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Structure of 1189105-60-9
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4-Bromo-8-(trifluoromethoxy)quinoline is a fluorinated quinoline derivative featuring a bromine substituent at the 4-position and a trifluoromethoxy group at the 8-position. This combination imparts enhanced electron-withdrawing character, improved metabolic stability, and favorable solubility for use in transition metal-catalyzed cross-coupling reactions. The molecule’s rigid aromatic core supports efficient π-stacking interactions, making it a valuable scaffold in medicinal chemistry and materials science applications.
4-Bromo-8-(trifluoromethoxy)quinoline serves as a versatile building block in medicinal chemistry and catalytic cross-coupling reactions. The bromo group enables palladium-catalyzed coupling with boronic acids, amines, and other nucleophiles, while the trifluoromethoxy substituent enhances metabolic stability and modulates lipophilicity. Its bench-stable nature and compatibility with standard reaction conditions facilitate efficient synthesis of complex heterocyclic scaffolds for drug discovery applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: